Weight-loss drugs have been front and center in recent years, making headlines for both their helpful benefits and their harrowing side effects. Jim LaValle, RPh, joins us to talk about how short-term use of GLP-1s — when used in combination with intentional lifestyle changes — may be a healthier path toward long-term weight management and overall health and well-being.
Jim LaValle, RPh, CCN, is a clinical pharmacist, the cochair of the American Academy of Anti-Aging Medicine, the chair of the International Peptide Society, and the Chief Science Officer for Life Time.
In this episode, LaValle shares a number of key things to know about GLP-1s and why taking a balanced approach in using them is advised.
- GLP-1 stands for glucagon-like peptide-1. Glucagon is a peptide that our bodies make naturally.
- GLP-1s can be a valuable tool for helping people who have perhaps tried other paths toward weight loss — through nutrition or exercise, for example — but have been unable to see results. GLP-1s need to be used in combination with lifestyle changes like nutrition and exercise though, emphasizes LaValle, and are not a “magic bullet,” as often portrayed.
- GLP-1s are touted at surface level for their weight-loss results, but better body composition often leads to reduced healthcare risks. This medication may be particularly useful for those with insulin resistance or type 2 diabetes because of their ability to help the body better regulate blood glucose.
- Food noise reduction is a benefit of GLP-1s — but it also means a well-formed nutrition plan is essential to ensure you don’t become nutrient deficient.
- Sufficient protein intake is critical when someone is on a GLP-1; it helps to preserve lean muscle mass. Regular strength training is also necessary for this reason.
- Proper titration of the medication is necessary, in part, to help avoid or temper the side effects that can result from starting on too high of a dose too quickly. There are distinct differences in dosage and usage between those who are using the medication to reset their metabolism and those who use it with or because of chronic illness.
- The goal is not for the use of this medication be ongoing; GLP-1s are a temporary tool in the toolbox, so to speak.
- Transitioning off GLP-1s should be done thoughtfully and in conjunction with lifestyle habits to help maintain weight loss.
- The journey of using a GLP-1 should be done in close partnership with trusted providers and support systems, emphasizes LaValle. Ongoing supervision is key to ensuring you have the proper plan in place and are being monitored so adjustments can be made as necessary throughout the time you’re on the medication.
Taking a Balanced Approach to GLP-1s
