S-Acetyl L-Glutathione LPT

This material is provided for educational and informational purposes only to licensed health care professionals. This information is obtained from sources believed to be reliable, but its accuracy cannot be guaranteed. Herbs and other natural substances are very powerful and can occasionally cause dangerous allergic reactions in a small percentage of the population. Licensed health care professionals should rely on sound professional judgment when recommending herbs and natural medicines to specific individuals. Individual use of herbs and natural medicines should be supervised by an appropriate health care professional. The use of any specific product should always be in accordance with the manufacturer’s directions.

 

Liposomal LPT chewable tabs provide a safe and more efficient way for the body to absorb nutrients, peptides and other targeted therapeutic compounds. LPT does not have stability problems that plague the liposomal industry – LPT are proven stable.

 

S-Acetyl Glutathione Uses:

• Ultimate antioxidant support
• Anti-aging support
• Supports detoxification including from environmental contaminants
• Dietary support in management of chronic health conditions
• Immune supportive

Dosage:

• S-acetyl, L-glutathione – 15 mg per LPT
• Chew and swallow 2 tablets daily

Background:

Glutathione is the most abundant antioxidant (called the “master” antioxidant) in our body, present in almost every cell. It plays a major role in controlling oxidative stress, supporting immunity (especially important during these times), and supporting detoxification of drugs and xenobiotics (chemicals foreign to us like pesticides, heavy metals, food additives/preservatives, industrial pollution, etc..).[1]  Intracellular depletion of glutathione ultimately results in cellular death, so keeping sufficient glutathione pools in the body is of paramount importance. Several studies report that plasma glutathione levels decrease with age, thus increasing the chances of developing chronic health conditions.[2]

Glutathione is made from three amino acids: glycine, cysteine and glutamic acid. This tripeptide exists in reduced (GSH) and oxidized (GSSG) forms. The relative amounts of each form determine the cellular redox status (GSH/GSSG ratio) which is often used as a marker of antioxidative capacity of cells.[3]

S-Acetyl-glutathione (SAG) is a GSH precursor which is more stable in plasma, it is taken up directly by the cells and later converted to GSH. S-acetyl L-glutathione is more bioavailable and therapeutically active.

GSH exhibits diverse physiological roles. It is a potent free radical and reactive oxygen species scavenger.[4] It reacts with various molecules (metabolites, xenobiotics) to form conjugates. GSH functions as a thiol buffer for many cellular proteins (metallothioneins, thioredoxins).[5] GSH is an essential cofactor for many enzymes and it is involved in several metabolic and signaling pathways.[6] GSH is also critical for the regeneration of other antioxidants such as tocopherols and ascorbate.[7]

GSH deficiency may be associated with oxidative stress, a condition that may play a key role in aging and in the pathogenesis of many chronic diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases, chronic inflammatory conditions and kidney/liver diseases.[8] GSH may exist in the cell in two forms: reduced glutathione (GSH) and oxidized glutathione (GSSG), which are in a  constant dynamic equilibrium.

Deficiency of glutathione is one of the major causes of serious health issues reported in COVID-19 patients.[9] The immune system works best if the lymphoid cells have a delicately balanced level of glutathione. Even moderate changes in the intracellular glutathione level have profound effects on lymphocyte functions, including NK cells (natural killer, elevated 4000% by 2 weeks post oral glutathione administration) and lymphocyte proliferation (up to 60% greater with oral glutathione).[10]^,[11]

 

Oral delivery of glutathione remains a huge challenge – issues in the GUT lead to very low oral bioavailability in humans.[12] This is mainly due to the action of the intestinal enzyme γ-glutamyl transpeptidase (GGT), which degrades GSH.[13] Although many approaches have been explored to improve delivery of glutathione, such as co-administration with penetration enhancers and enzymatic inhibitors, or encapsulation into nanoparticles, microemulsions and liposomes, appropriate formulations with clinical therapeutic effects remain to be developed. However, recent advances in oral liposomal technology have allowed for the best bioavailable glutathione on the market – S-Acetyl Glutathione LPT.

 

 

GSH intake via the oral route does not successfully enhance GSH in plasma, due to its metabolization in the gut. Hence, many attempts have been made to develop GSH derivatives able to easily cross the cell membranes and to enhance its oral bioavailability. S-Acetyl Glutathione LPT takes care of these absorption issues so you can be assured of the complete beneficial effects of glutathione on the body.

 

Clinical applications of glutathione include:[14]^,[15]^,[16]

• Aging and Longevity
• Chronic inflammation – metaflammation
• Neurodegenerative disorders(cognitive decline, dementia, Alzheimer’s, Parkinson’s, and Huntington’s diseases, amyotrophic lateral sclerosis, Friedreich’s ataxia)
• Pulmonary disease(COPD, asthma, and acute respiratory distress syndrome), HIV issues
• Immune conditions(HIV, autoimmune disease, poor immune responses)
• Cardiovascular diseases(hypertension, myocardial infarction, cholesterol oxidation, atherosclerosis)
• Chronic aging issues(cataracts, macular degeneration, hearing impairment, glaucoma, muscle loss, tissue building/repairing)
• Liver diseases – improving detoxification processes
• Kidney diseases
• Cystic fibrosis
• Alcohol and drug abuse/addiction

 

Why Lipotabs?

The revolutionary Liposomal LPT chewable tabs provide a safe and more efficient way for the body to absorb nutrients, peptides and other targeted therapeutic compounds. LPT does not have stability problems that plague the liposomal industry – LPT are proven stable.

 

Liquid liposomal products have inherent stability issues. Issues with Liquid Liposomes on the Market include:

• Needs significant heat to produce – makes product unstable and decomposes active and inert ingredients in the product
• Particles clump together to form larger and larger particle size
  • Liquid liposomes reported to grow from 100nm size to 3000nm over a 30-day period[1]
  • Larger particle size means less bioavailable
  • Larger size also means increased potential for side-effects

 LPT particles don’t require heat for production and don’t “clump” like liquid liposomes over time

• Means Greater Bioavailability
• Greater Stability
• Superior Product
• Superior Results
• No toxic excipients

Lipotabs are safe, chewable, oral liposomal tablets manufactured using patented, small molecule technology to improve bioavailability and biological effects.

 

Copyright © 2023 James B. LaValle, Natural Formulations All rights reserved.

 

No part of this material may be used or reproduced in any manner whatsoever, stored in a retrieval system, or transmitted in any form, or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission of the author.

 

This material is provided for educational and informational purposes only to licensed health care professionals. This information is obtained from sources believed to be reliable, but its accuracy cannot be guaranteed. Herbs and other natural substances are very powerful and can occasionally cause dangerous allergic reactions in a small percentage of the population. Licensed health care professionals should rely on sound professional judgment when recommending herbs and natural medicines to specific individuals. Individual use of herbs and natural medicines should be supervised by an appropriate health care professional. The use of any specific product should always be in accordance with the manufacturer’s directions.

 

[1] Lombardo D, Kiselev MA. Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application. Pharmaceutics. 2022;14(3):543.

[1] Pizzorno J. Glutathione. Integr Med (Encinatas). 2014;13(1):8-12.

[2]  Jones DP, et al. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses. Free Radic. Biol. Med. 2002;33:1290–1300.

[3] Schmitt B, et al. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015;6:198-205.

[4] Jones D.P. Redefining oxidative stress. Antioxid. Redox Signal. 2006;8:1865–1879.

[5] Ketterer B., Coles B., Meyer D.J. The role of glutathione in detoxication. Environ. Health Perspect. 1983;49:59–69.

[6] Sen C.K. Redox signaling and the emerging therapeutic potential of thiol antioxidants. Biochem. Pharmacol. 1998;55:1747–1758.

[7] Meister A. Glutathione, ascorbate, and cellular protection. Cancer Res. 1994;54:1969s–1975s.

[8] Fanelli S, et al. Oral Administration of S-acetyl-glutathione: Impact on the Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers. Int J Clin Nutr Dietetics. 2018;4(4):IJCND-134.

[9] Polonikov A. Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis. 2020;  acsinfecdis.0c00288.

[10] Droge W, Breitkreutz R. Glutathione and immune function. Proc Nutr Soc. .2000;59(4):595-600.

[11] Sinha R, et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018;72(1):105-111.

[12] Wei T, et al. Oral delivery of glutathione: antioxidant function , barriers and strategies. Acta Materia Medica. 2022;

[13] Zhang H., et al. Gamma-glutamyl transpeptidase in glutathione biosynthesis. Methods Enzymol. 2005;401:468–483.

[14] Homma T, Fuji J. Application of glutathione as anti-oxidative and anti-aging drugs. Curr Drug Metab. 2015;16(7):560-71.

[15] Kumar P, et al. Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial. Clin Transl Med. 2021;11(3):e372.

[16] Lizzo G, et al. A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. Front Aging. 2022;3:852569.