Liquid liposomes are the most popular delivery method.
- Why? They are the easiest to make.
Liquid liposomes require heat.
- Makes product thermodynamically unstable.
- Decomposes active and inactive/inert ingredients (phospholipids).
Liquid liposome leakage rate increases over time, which in-turn shortens the shelf-life of the product.
Liquid liposome particles clump together to form larger and larger particle size.
- Liquid liposomes reported to grow from 100nm size to 3000nm over a 30-day period⁴.
- Larger particle size means less bioavailable.
- Larger size also means increased potential for side-effects.

